The Li lab is broadly interested in neuroimmunology, with a specific focus on microglial biology in health and disease. Current projects primarily utilize rodent models to study mechanisms underlying the generation and plasticity of microglial states, as well as their functional implications in development, aging, and neurodegenerative diseases (Barclay et al. Immunity. 2024). The overarching goal is to leverage cutting-edge genomic technologies alongside novel molecular and genetic tools to investigate microglial development, heterogeneity, and mechanisms of neuro-immune interactions that impact brain structure and disease.
News
Our paper on using the novel Clec7a-CreER mouse to label, track and manipulate PAM/DAM microglial states is finally out in Immunity! Congrats to the first author Kia Barclay! – 5.30.2024
Join Us
We welcome researchers at all levels to join our lab! We are committed to a diverse, collaborative and equitable work environment where every member can thrive and grow.
Follow us on X @TristanLi_Lab
Location
Li Lab
Jeffrey T. Fort Neuroscience Research Building
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Mailing Address:
4370 Duncan Avenue,
Floor: 07 Room 07350
St. Louis, MO 63110