Publications

Selected Publications

• Barclay KM, Abduljawad N, Cheng Z, Kim MW, Zhou L, Yang J, Rustenhoven J, Mazzitelli JA, Smyth LCD, Kapadia D, Brioschi S, Beatty W, Hou J, Saligrama N, Colonna M, Yu G, Kipnis J, Li Q. An inducible genetic tool to track and manipulate specific microglial states reveals their plasticity and roles in remyelination. Immunity. 2024 Jun 11;57(6):1394-1412.e8. doi: 10.1016/j.immuni.2024.05.005. Epub 2024 May 30. PubMed PMID: 38821054; NIHMSID:NIHMS1999302.
• Li Q, Haney MS. The role of glia in protein aggregation. Neurobiol Dis. 2020 Sep;143:105015. doi: 10.1016/j.nbd.2020.105015. Epub 2020 Jul 12. Review. PubMed PMID: 32663608.select
• A single-cell transcriptomic atlas characterizes ageing tissues in the mouse. Nature. 2020 Jul;583(7817):590-595. doi: 10.1038/s41586-020-2496-1. Epub 2020 Jul 15. PubMed PMID: 32669714; PubMed Central PMCID: PMC8240505.select
• Li Q, Cheng Z, Zhou L, Darmanis S, Neff NF, Okamoto J, Gulati G, Bennett ML, Sun LO, Clarke LE, Marschallinger J, Yu G, Quake SR, Wyss-Coray T, Barres BA. Developmental Heterogeneity of Microglia and Brain Myeloid Cells Revealed by Deep Single-Cell RNA Sequencing. Neuron. 2019 Jan 16;101(2):207-223.e10. doi: 10.1016/j.neuron.2018.12.006. Epub 2018 Dec 31. PubMed PMID: 30606613; PubMed Central PMCID: PMC6336504.select
• Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris. Nature. 2018 Oct;562(7727):367-372. doi: 10.1038/s41586-018-0590-4. Epub 2018 Oct 3. PubMed PMID: 30283141; PubMed Central PMCID: PMC6642641.select
• Li Q, Barres BA. Microglia and macrophages in brain homeostasis and disease. Nat Rev Immunol. 2018 Apr;18(4):225-242. doi: 10.1038/nri.2017.125. Epub 2017 Nov 20. Review. PubMed PMID: 29151590.select

All Publications

• Barclay KM, Abduljawad N, Cheng Z, Kim MW, Zhou L, Yang J, Rustenhoven J, Mazzitelli JA, Smyth LCD, Kapadia D, Brioschi S, Beatty W, Hou J, Saligrama N, Colonna M, Yu G, Kipnis J, Li Q. An inducible genetic tool to track and manipulate specific microglial states reveals their plasticity and roles in remyelination. Immunity. 2024 Jun 11;57(6):1394-1412.e8. doi: 10.1016/j.immuni.2024.05.005. Epub 2024 May 30. PubMed PMID: 38821054; NIHMSID:NIHMS1999302.
• Li Q. TIMely connections: APOE4, aging, and Alzheimer’s. Immunity. 2024 Jan 9;57(1):8-10. doi: 10.1016/j.immuni.2023.12.015. PubMed PMID: 38198855.
• Li Q. Pituitary-immune bidirectional crosstalk under systemic inflammation. PLoS Biol. 2023 Dec;21(12):e3002440. doi: 10.1371/journal.pbio.3002440. eCollection 2023 Dec. PubMed PMID: 38113236; PubMed Central PMCID: PMC10729977.
• Vasek MJ, Mueller SM, Fass SB, Deajon-Jackson JD, Liu Y, Crosby HW, Koester SK, Yi J, Li Q, Dougherty JD. Local translation in microglial processes is required for efficient phagocytosis. Nat Neurosci. 2023 Jul;26(7):1185-1195. doi: 10.1038/s41593-023-01353-0. Epub 2023 Jun 5. PubMed PMID: 37277487; PubMed Central PMCID: PMC10580685.select
• Brioschi S, Belk JA, Peng V, Molgora M, Rodrigues PF, Nguyen KM, Wang S, Du S, Wang WL, Grajales-Reyes GE, Ponce JM, Yuede CM, Li Q, Baer JM, DeNardo DG, Gilfillan S, Cella M, Satpathy AT, Colonna M. A Cre-deleter specific for embryo-derived brain macrophages reveals distinct features of microglia and border macrophages. Immunity. 2023 May 9;56(5):1027-1045.e8. doi: 10.1016/j.immuni.2023.01.028. Epub 2023 Feb 14. PubMed PMID: 36791722; PubMed Central PMCID: PMC10175109.
• Xu J, Farsad HL, Hou Y, Barclay K, Lopez BA, Yamada S, Saliu IO, Shi Y, Knight WC, Bateman RJ, Benzinger TLS, Yi JJ, Li Q, Wang T, Perlmutter JS, Morris JC, Zhao G. Human striatal glia differentially contribute to AD- and PD-specific neurodegeneration. Nat Aging. 2023 Mar;3(3):346-365. doi: 10.1038/s43587-023-00363-8. Epub 2023 Feb 9. PubMed PMID: 36993867; PubMed Central PMCID: PMC10046522.select
• Pálovics R, Keller A, Schaum N, Tan W, Fehlmann T, Borja M, Kern F, Bonanno L, Calcuttawala K, Webber J, McGeever A, Luo J, Pisco AO, Karkanias J, Neff NF, Darmanis S, Quake SR, Wyss-Coray T. Molecular hallmarks of heterochronic parabiosis at single-cell resolution. Nature. 2022 Mar;603(7900):309-314. doi: 10.1038/s41586-022-04461-2. Epub 2022 Mar 2. PubMed PMID: 35236985; PubMed Central PMCID: PMC9387403.select
• Sayed FA, Kodama L, Fan L, Carling GK, Udeochu JC, Le D, Li Q, Zhou L, Wong MY, Horowitz R, Ye P, Mathys H, Wang M, Niu X, Mazutis L, Jiang X, Wang X, Gao F, Brendel M, Telpoukhovskaia M, Tracy TE, Frost G, Zhou Y, Li Y, Qiu Y, Cheng Z, Yu G, Hardy J, Coppola G, Wang F, DeTure MA, Zhang B, Xie L, Trajnowski JQ, Lee VMY, Gong S, Sinha SC, Dickson DW, Luo W, Gan L. AD-linked R47H-TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation. Sci Transl Med. 2021 Dec;13(622):eabe3947. doi: 10.1126/scitranslmed.abe3947. Epub 2021 Dec 1. PubMed PMID: 34851693; PubMed Central PMCID: PMC9345574.select
• Li Q, Haney MS. The role of glia in protein aggregation. Neurobiol Dis. 2020 Sep;143:105015. doi: 10.1016/j.nbd.2020.105015. Epub 2020 Jul 12. Review. PubMed PMID: 32663608.select
• Schaum N, Lehallier B, Hahn O, Pálovics R, Hosseinzadeh S, Lee SE, Sit R, Lee DP, Losada PM, Zardeneta ME, Fehlmann T, Webber JT, McGeever A, Calcuttawala K, Zhang H, Berdnik D, Mathur V, Tan W, Zee A, Tan M, Pisco AO, Karkanias J, Neff NF, Keller A, Darmanis S, Quake SR, Wyss-Coray T. Ageing hallmarks exhibit organ-specific temporal signatures. Nature. 2020 Jul;583(7817):596-602. doi: 10.1038/s41586-020-2499-y. Epub 2020 Jul 15. PubMed PMID: 32669715; PubMed Central PMCID: PMC7757734.select
• A single-cell transcriptomic atlas characterizes ageing tissues in the mouse. Nature. 2020 Jul;583(7817):590-595. doi: 10.1038/s41586-020-2496-1. Epub 2020 Jul 15. PubMed PMID: 32669714; PubMed Central PMCID: PMC8240505.select
• Gibson EM, Bennett FC, Gillespie SM, Güler AD, Gutmann DH, Halpern CH, Kucenas SC, Kushida CA, Lemieux M, Liddelow S, Macauley SL, Li Q, Quinn MA, Roberts LW, Saligrama N, Taylor KR, Venkatesh HS, Yalçın B, Zuchero JB. How Support of Early Career Researchers Can Reset Science in the Post-COVID19 World. Cell. 2020 Jun 25;181(7):1445-1449. doi: 10.1016/j.cell.2020.05.045. Epub 2020 Jun 12. PubMed PMID: 32533917; PubMed Central PMCID: PMC7291965.select
• Li Q. Overseeing Memory Circuits by NFIA: New Face In Astrocytes. Neuron. 2020 Jun 17;106(6):878-880. doi: 10.1016/j.neuron.2020.05.027. PubMed PMID: 32553203.select
• Kodama L, Guzman E, Etchegaray JI, Li Y, Sayed FA, Zhou L, Zhou Y, Zhan L, Le D, Udeochu JC, Clelland CD, Cheng Z, Yu G, Li Q, Kosik KS, Gan L. Microglial microRNAs mediate sex-specific responses to tau pathology. Nat Neurosci. 2020 Feb;23(2):167-171. doi: 10.1038/s41593-019-0560-7. Epub 2019 Dec 23. PubMed PMID: 31873194; PubMed Central PMCID: PMC7394069.select
• Zhou L, Li Q. Isolation of Region-specific Microglia from One Adult Mouse Brain Hemisphere for Deep Single-cell RNA Sequencing. J Vis Exp. 2019 Dec 3;(154). doi: 10.3791/60347. PubMed PMID: 31868174.select
• Marton RM, Miura Y, Sloan SA, Li Q, Revah O, Levy RJ, Huguenard JR, Pașca SP. Differentiation and maturation of oligodendrocytes in human three-dimensional neural cultures. Nat Neurosci. 2019 Mar;22(3):484-491. doi: 10.1038/s41593-018-0316-9. Epub 2019 Jan 28. PubMed PMID: 30692691; PubMed Central PMCID: PMC6788758.select
• Li Q, Cheng Z, Zhou L, Darmanis S, Neff NF, Okamoto J, Gulati G, Bennett ML, Sun LO, Clarke LE, Marschallinger J, Yu G, Quake SR, Wyss-Coray T, Barres BA. Developmental Heterogeneity of Microglia and Brain Myeloid Cells Revealed by Deep Single-Cell RNA Sequencing. Neuron. 2019 Jan 16;101(2):207-223.e10. doi: 10.1016/j.neuron.2018.12.006. Epub 2018 Dec 31. PubMed PMID: 30606613; PubMed Central PMCID: PMC6336504.select
• Sun LO, Mulinyawe SB, Collins HY, Ibrahim A, Li Q, Simon DJ, Tessier-Lavigne M, Barres BA. Spatiotemporal Control of CNS Myelination by Oligodendrocyte Programmed Cell Death through the TFEB-PUMA Axis. Cell. 2018 Dec 13;175(7):1811-1826.e21. doi: 10.1016/j.cell.2018.10.044. Epub 2018 Nov 29. PubMed PMID: 30503207; PubMed Central PMCID: PMC6295215.select
• Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris. Nature. 2018 Oct;562(7727):367-372. doi: 10.1038/s41586-018-0590-4. Epub 2018 Oct 3. PubMed PMID: 30283141; PubMed Central PMCID: PMC6642641.select
• Li Q, Barres BA. Microglia and macrophages in brain homeostasis and disease. Nat Rev Immunol. 2018 Apr;18(4):225-242. doi: 10.1038/nri.2017.125. Epub 2017 Nov 20. Review. PubMed PMID: 29151590.select
• Pan JW, Li Q, Barish S, Okuwa S, Zhao S, Soeder C, Kanke M, Jones CD, Volkan PC. Patterns of transcriptional parallelism and variation in the developing olfactory system of Drosophila species. Sci Rep. 2017 Aug 18;7(1):8804. doi: 10.1038/s41598-017-08563-0. PubMed PMID: 28821769; PubMed Central PMCID: PMC5562767.select
• Barish S, Li Q, Pan JW, Soeder C, Jones C, Volkan PC. Transcriptional profiling of olfactory system development identifies distal antenna as a regulator of subset of neuronal fates. Sci Rep. 2017 Jan 19;7:40873. doi: 10.1038/srep40873. PubMed PMID: 28102318; PubMed Central PMCID: PMC5244397.select
• Hueston CE, Olsen D, Li Q, Okuwa S, Peng B, Wu J, Volkan PC. Chromatin Modulatory Proteins and Olfactory Receptor Signaling in the Refinement and Maintenance of Fruitless Expression in Olfactory Receptor Neurons. PLoS Biol. 2016 Apr;14(4):e1002443. doi: 10.1371/journal.pbio.1002443. eCollection 2016 Apr. PubMed PMID: 27093619; PubMed Central PMCID: PMC4836687.select
• Li Q, Barish S, Okuwa S, Maciejewski A, Brandt AT, Reinhold D, Jones CD, Volkan PC. A Functionally Conserved Gene Regulatory Network Module Governing Olfactory Neuron Diversity. PLoS Genet. 2016 Jan;12(1):e1005780. doi: 10.1371/journal.pgen.1005780. eCollection 2016 Jan. PubMed PMID: 26765103; PubMed Central PMCID: PMC4713227.select
• Li Q, Barish S, Okuwa S, Volkan PC. Examination of Endogenous Rotund Expression and Function in Developing Drosophila Olfactory System Using CRISPR-Cas9-Mediated Protein Tagging. G3 (Bethesda). 2015 Oct 23;5(12):2809-16. doi: 10.1534/g3.115.021857. PubMed PMID: 26497147; PubMed Central PMCID: PMC4683652.select
• Li C, Xu J, Li J, Li Q, Yang H. Involvement of Arabidopsis HAC family genes in pleiotropic developmental processes. Plant Signal Behav. 2014;9(3):e28173. doi: 10.4161/psb.28173. Epub 2014 Mar 10. PubMed PMID: 24614176; PubMed Central PMCID: PMC4091543.select
• Li C, Xu J, Li J, Li Q, Yang H. Involvement of Arabidopsis histone acetyltransferase HAC family genes in the ethylene signaling pathway. Plant Cell Physiol. 2014 Feb;55(2):426-35. doi: 10.1093/pcp/pct180. Epub 2013 Nov 28. PubMed PMID: 24287137.select
• Li Q, Ha TS, Okuwa S, Wang Y, Wang Q, Millard SS, Smith DP, Volkan PC. Combinatorial rules of precursor specification underlying olfactory neuron diversity. Curr Biol. 2013 Dec 16;23(24):2481-90. doi: 10.1016/j.cub.2013.10.053. Epub 2013 Nov 21. PubMed PMID: 24268416; PubMed Central PMCID: PMC4459592.
• Simmons Kovacs LA, Mayhew MB, Orlando DA, Jin Y, Li Q, Huang C, Reed SI, Mukherjee S, Haase SB. Cyclin-dependent kinases are regulators and effectors of oscillations driven by a transcription factor network. Mol Cell. 2012 Mar 9;45(5):669-79. doi: 10.1016/j.molcel.2011.12.033. Epub 2012 Feb 2. PubMed PMID: 22306294; PubMed Central PMCID: PMC3578314.